Extrapolation of pharmacokinetics and pharmacodynamics of sunitinib in children with gastrointestinal stromal tumors

ConclusionBased on PK, safety, and efficacy trial simulations, a sunitinib starting dose of  ~ 25 mg/m2/day was predicted to provide comparable plasma drug exposures in children with GIST as in adults with GIST treated with 50  mg/day. However, in the absence of a tumor type effect of sunitinib on CL/F in children, the projected equivalent dose for this population would be ~ 20 mg/m2/day.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research