BH4 Increases nNOS Activity and Preserves Left Ventricular Function in Diabetes.

Conclusions: We uncovered a novel mechanism whereby myocardial BH4 prevents and reverses LV diastolic and systolic dysfunction associated with diabetes via a nNOS-mediated increase in non-insulin dependent myocardial glucose uptake and utilization. These findings highlight the potential of GCH1/BH4-based therapeutics in human diabetic cardiomyopathy.
PMID: 33494625 [PubMed - as supplied by publisher]

Source: Circulation Research - January 26, 2021 Category: Cardiology Authors: Carnicer Hijazo R, Duglan D, Ziberna K, Recalde A, Reilly S, Simon JN, Mafrici S, Arya R, Roselló-Lletí E, Chuaiphichai S, Tyler DJ, Lygate CA, Channon KM, Casadei B Tags: Circ Res Source Type: research