Association of Severe Lymphopenia and Disease Progression in Unresectable Locally Advanced Non-Small Cell Lung Cancer Treated with Definitive Chemoradiation and Immunotherapy

The immune system plays a crucial role in cancer surveillance and anti-tumor activity. Lymphocytes are integral in the immune tumor response, assisting in adaptive and immune responses and direct destruction of tumor cells [1 –3]. Additionally, immune checkpoint inhibitors (ICIs) that block programmed death-ligand 1 (PD-L1), programmed death 1 (PD-1), or cytotoxic t-lymphocyte-associated protein 4 (CTLA-4) receptors have been utilized to upregulate T-cell activity and improve tumor cell killing [4–6].

Source: Lung Cancer - January 27, 2021 Category: Cancer & Oncology Authors: Cole Friedes, Turja Chakrabarti, Sarah Olson, Laura Prichett, Julie R. Brahmer, Patrick J. Forde, Ranh K. Voong, Kristen A. Marrone, Vincent K. Lam, Christine L. Hann, Stephen R. Broderick, Richard J. Battafarano, Jinny S. Ha, Errol L. Bush, Stephen C Yan Source Type: research