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An international study allows a better prediction of the risk of hereditary cancer

(IDIBELL-Bellvitge Biomedical Research Institute) An international study has developed a refined method to identify people at risk for certain inherited cancer as a result of Lynch syndrome. The study, published in Nature Genetics has carried out clinical and basic researchers who are part of the INSIGHT (International Society for Gastroeintestinal Hereditary Tumours).
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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(Springer) Individuals with Lynch syndrome, a genetic condition that has long been known to carry dramatically increased risk of colorectal cancer and uterine cancer, now also have an increased risk of breast cancer. This is the conclusion of a study in the journal Genetics in Medicine which is published by Springer Nature.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Columbia University Medical Center) Columbia University researchers have identified two new breast cancer genes that also cause Lynch syndrome.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Future Oncology, Ahead of Print.
Source: Future Oncology - Category: Cancer & Oncology Authors: Source Type: research
MSH6 and PMS2 germ-line pathogenic variants implicated in Lynch syndrome are associated with breast cancer, Published online: 18 January 2018; doi:10.1038/gim.2017.254MSH6 and PMS2 germ-line pathogenic variants implicated in Lynch syndrome are associated with breast cancer
Source: Genetics in Medicine - Category: Genetics & Stem Cells Authors: Source Type: research
ConclusionsTherefore, compared with Lynch-syndrome-associated cancers, sporadic MSI cancers are more frequently solid, poorly differentiated medullary cancers that express PD-L1.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Therefore, compared with Lynch-syndrome-associated cancers, sporadic MSI cancers are more frequently solid, poorly differentiated medullary cancers that express PD-L1. PMID: 29327160 [PubMed - as supplied by publisher]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Int J Clin Oncol Source Type: research
Conclusion: These results provide the actual percentage of family or personal history of cancer that can be attributed to pathogenic or likely pathogenic variants in one or more of the genes on our panel and corroborate the utility of multi-gene panels over sequential testing to identify individuals with an inherited predisposition to cancer. PMID: 29308099 [PubMed]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: Hered Cancer Clin Pract Source Type: research
ConclusionThese results provide the actual percentage of family or personal history of cancer that can be attributed to pathogenic or likely pathogenic variants in one or more of the genes on our panel and corroborate the utility of multi-gene panels over sequential testing to identify individuals with an inherited predisposition to cancer.
Source: Hereditary Cancer in Clinical Practice - Category: Cancer & Oncology Source Type: research
Microcystic, elongated, and fragmented (MELF) pattern invasion is a poor prognostic indicator in uterine endometrioid carcinoma, but its existence, biology, and prognostic value have not been described in ovarian endometrioid carcinoma. We evaluated cases of ovarian endometrioid carcinoma without synchronous uterine endometrioid carcinoma for MELF and other histologic features. To evaluate tumor biology, we assessed an immunohistochemical profile, including MLH1, PMS2, MSH2, MSH6, β-catenin, e-cadherin, CK19, and cyclin D1. A retrospective chart review evaluated clinical and demographic features and survival. The Fish...
Source: International Journal of Gynecological Pathology - Category: Pathology Tags: Pathology of the Upper Genital Tract: Original Articles Source Type: research
ConclusionsUniversal IHC screening of SNs is an effective method to identify cases for further genetic evaluation. Rates of referral to clinical genetics were only moderate (58%). Increased awareness of MTS could help improve the rate of onward referral.
Source: Clinical And Experimental Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
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