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The Study of Diabetic Nephropathy With Atrasentan (SONAR) and Evaluation of the Effects of Canagliflozin on Renal and  Cardiovascular Outcomes in Participants With Diabetic Nephropathy (CREDENCE) trials showed kidney-protective effects of an endothelin A receptor antagonist (ERA) and a sodium glucose co-transporter 2 (SGLT2) inhibitor in patients with type-2 diabetes and chronic kidney disease, respectively. A lim iting effect of ERA is fluid retention, and diuresis is a consequence of SGLT2 inhibition.
Source: Kidney International - Category: Urology & Nephrology Tags: In This Issue Source Type: research