The PI3-kinase p110 β isoform controls severity of cocaine-induced sequelae and alters the striatal transcriptome

The PI3-kinase (PI3K) complex is a well-validated target for mitigating cocaine-elicited sequelae, but pan-PI3-kinase inhibitors are not viable long-term treatment options. The PI3K complex is composed of p110 catalytic and regulatory subunits, which can be individually manipulated for therapeutic purposes. This possibility has largely not, however, been explored in behavioral contexts.

Source: Biological Psychiatry - January 25, 2021 Category: Psychiatry Authors: Lauren P. Shapiro, Elizabeth G. Pitts, Dan C. Li, Britton R. Barbee, Elizabeth A. Hinton, Gary J. Bassell, Christina Gross, Shannon L. Gourley Tags: Priority Communication Source Type: research