SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress [Cell Biology]

Adaptation to different forms of environmental stress is crucial for maintaining essential cellular functions and survival. The nucleolus plays a decisive role as a signaling hub for coordinating cellular responses to various extrinsic and intrinsic cues. p53 levels are normally kept low in unstressed cells, mainly due to E3 ubiquitin...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Cell Biology Biological Sciences Source Type: research