SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress [Cell Biology]
Adaptation to different forms of environmental stress is crucial for maintaining essential cellular functions and survival. The nucleolus plays a decisive role as a signaling hub for coordinating cellular responses to various extrinsic and intrinsic cues. p53 levels are normally kept low in unstressed cells, mainly due to E3 ubiquitin...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Alessandro Ianni, Poonam Kumari, Shahriar Tarighi, Nicolas G. Simonet, Daniela Popescu, Stefan Guenther, Soraya Holper, Andreas Schmidt, Christian Smolka, Shiȷing Yue, Marcus Kruger, Claudia Fiorillo, Aleȷandro Vaquero, Eva Bober, Thomas Bra Tags: Cell Biology Biological Sciences Source Type: research