Replication-independent instability of Friedreich’s ataxia GAA repeats during chronological aging [Genetics]

Nearly 50 hereditary diseases result from the inheritance of abnormally long repetitive DNA microsatellites. While it was originally believed that the size of inherited repeats is the key factor in disease development, it has become clear that somatic instability of these repeats throughout an individual’s lifetime strongly contributes to disease...

Source: Proceedings of the National Academy of Sciences - January 25, 2021 Category: Science Authors: Alexander J. Neil, Julia A. Hisey, Ishtiaque Quasem, Ryan J. McGinty, Marcin Hitczenko, Alexandra N. Khristich, Sergei M. Mirkin Tags: Genetics Biological Sciences Source Type: research