Microtubule inhibitors impede DNA repair proteins [Medical Sciences]

The paradigm that microtubule-targeting agents (MTAs) cause cell death via mitotic arrest applies to rapidly dividing cells but cannot explain MTA activity in slowly growing human cancers. Many preferred cancer regimens combine a MTA with a DNA-damaging agent (DDA). We hypothesized that MTAs synergize with DDAs by interfering with trafficking...

Source: Proceedings of the National Academy of Sciences - February 3, 2015 Category: Science Authors: Poruchynsky, M. S., Komlodi-Pasztor, E., Trostel, S., Wilkerson, J., Regairaz, M., Pommier, Y., Zhang, X., Kumar Maity, T., Robey, R., Burotto, M., Sackett, D., Guha, U., Fojo, A. T. Tags: Biological Sciences Source Type: research