Universal therapeutic targeting of age-related protein quality control system dysfunction in chronic diseases?

Aging is inevitable. Aging constitutes a principal risk factor for most, if not all chronic disorders including heart disease. Although the rate and degree to which a person ages is a reflection of their genetics, family history, environment and life style, ultimately the age-related underlying proteomic changes occur that widely affect all aspects of cell physiology. There still lacks a complete mechanistic understanding of how aging alters the proteome. Even so, numerous pathways and processes involved in aging have been implicated including age-related dysfunction of the protein quality control (PQC) processes.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research