Calm Down When the Heart Is Stressed– inhibiting calmodulin-dependent protein kinase II for antiarrhythmias

Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays a pivotal role in many regulatory processes of cellular functions ranging from membrane potentials and electric-contraction (E-C) coupling to mitochondrial integrity and survival of cardiomyocytes. The review article by Hund and Mohler in this issue of Trends in Cardiovascular Medicine highlights the importance of the elevated CaMKII signaling pathways under stressed conditions such as myocardial hypertrophy and ischemia in the detrimental remodeling of ion channels and in the genesis of cardiac arrhythmias.

Source: Trends in Cardiovascular Medicine - February 4, 2015 Category: Cardiology Authors: Dayue Darrel Duan Source Type: research