In Vitro Fertilization for Polycystic Ovarian Syndrome

In vitro fertilization is indicated for infertile women with polycystic ovarian syndrome (PCOS) after unsuccessful treatment with ovulation induction agents or in women deemed high-risk of multiple gestations who are ideal candidates for single embryo transfers. PCOS patients are at increased risk of ovarian hyperstimulation syndrome; therefore, attention should be made in the choice of in vitro fertilization treatment protocol, dose of gonadotropin utilized, and regimen to achieve final oocyte maturation. Adopting these strategies in addition to close monitoring may significantly reduce the ovarian hyperstimulation syndrome risk. Future developments may improve pregnancy outcomes and decrease complications in PCOS women undergoing fertility treatment.
Source: Clinical Obstetrics and Gynecology - Category: OBGYN Tags: Polycystic Ovary Disease Source Type: research

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Eur Rev Med Pharmacol Sci. 2021 Jul;25(14):4799-4809. doi: 10.26355/eurrev_202107_26393.ABSTRACTPolycystic ovary syndrome (PCOS) is an endo-crine disorder that occurs in 8-10% of women of reproduc-tive age. It is characterized by oligo or anovulation, hyperandrogenism and/or polycystic ovaries, but also by an increased insulin plasma level especially in overweight/obese women or in those with familial diabetes. In the last years, among the insulin sensitizers, the use of the two active isoforms of inositols (myo-inositol and d-chiro-inositol) has been spreading for the treatment of PCOS insulin resistance. Several studies ...
Source: Pharmacological Reviews - Category: Drugs & Pharmacology Authors: Source Type: research
Polycystic ovaries syndrome (PCOS) is characterized by hormonal and metabolic imbalances that affect many aspects of a woman ’s life: physical appearance, menstruation cycle, reproductive health and more. While the exact cause of PCOS is unknown, it is clear that PCOS varies in presentation. Researchers are constantly investigating factors that may cause or contribute to infertility in women with PCOS. One of these fact ors include serum anti-mullerian hormone (AMH) levels. AMH levels are a strong indicator of a woman’s ovarian reserve and as a result, it is often measured to predict a woman's chances at a successful pregnancy.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster presentation Source Type: research
This study was supported by Shandong Provincial Natural Science Foundation, China [ZR2020MH064 to X.C.], Shandong Province Medical and Health Technology Development Plan [2018WS338 to X.C.], the joint research funding of Shandong University and Karolinska Institute [SDU-KI-2019-08 to X.C. and C.L.], the Finnish Institute for Health and Welfare: Drug and Pregnancy Project [M.G.], the Swedish Research Council [2014-10171 to C.L.], the regional agreement on medical training and clinical research (ALF) between Stockholm County Council and Karolinska Institute Stockholm County Council [SLL20170292 and SLL20190589 to C.L.], the ...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research
This study was designed to compare the endocrine and metabolic parameters as well as subjective and objective measures of stress in women with PCOS before and after treatment with acetyl-l-carnitine (ALC) and metformin plus pioglitazone.MethodsA total of 147 women with PCOS were randomly assigned into two groups: the combo group (n = 72) received a combination of metformin, pioglitazone, and ALC (500 mg, 15 mg, and 1500 mg, respectively), twice daily; the Met + Pio group (n = 75) received metformin plus pioglitazone (500 mg, 15 mg, respectively) and placebo...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
ConclusionOur data indicates disrupted redox homeostasis in follicular environment in PCOS which may negatively influence oocyte/embryo quality. Further, granulosa cells may play crucial role in maintaining follicular redox homeostasis. Glutathione system and paraoxonase1 could be explored further as surrogates for IVF prognosis/outcome.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
CONCLUSION: A higher probability of ovulation is expected in infertile patients with PCOS treated with letrozole as compared to CC. The higher ovulation rate might have contributed to the higher clinical pregnancy and live birth rate. This finding is also true for patients who were administered letrozole as first-line treatment.TRIAL REGISTRATION: CRD42019125166.PMID:34033068 | DOI:10.1007/s42000-021-00289-z
Source: Hormones - Category: Endocrinology Authors: Source Type: research
Polycystic ovary syndrome is a hormonal disorder common among women of reproductive age. Complications can include infertility, gestational diabetes or pregnancy-induced high blood pressure, miscarriage or premature birth, and endometrial cancer. Signs and symptoms of polycystic ovary syndrome vary. A diagnosis is made when women experience at least two of these signs: Irregular periods.Elevated levels of male [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news
Often, the skin can be a window to what is occurring inside your body. For women with polycystic ovary syndrome, or PCOS, this this may mean acne, hair loss, excessive facial or body hair growth, dark patches on the skin, or any combination of these issues. What is PCOS? Skin and hair issues can be the most readily perceptible features of PCOS, and thus sometimes the reason for seeking medical care. However, features of PCOS also include menstrual irregularities, polycystic ovaries (when the ovaries develop multiple small follicles and do not regularly release eggs), obesity, and insulin resistance (when cells do not respo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Diet and Weight Loss Family Planning and Pregnancy Fertility Skin and Hair Care Women's Health Source Type: blogs
The objectives of this study were to determine the associations of MetS with OI live birth rate and pregnancy complications in obese women with PCOS, and to see if these outcomes differ by specific agent used for OI.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Original Research: Gynecology Source Type: research
ConclusionsNonsurgical therapeutic strategies that promote superior IS improvement may aid infertile PCOS women to increase their possibility of successful pregnancy regardless of the various interventions. The improvement of IS might be more important than the reduction of BMI in the improvement of pregnancy rate in infertile PCOS women.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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