The effects of selective serotonin reuptake inhibitors on male and female fertility: a brief literature review.

Conclusions: SSRIs should be avoided male patients of reproductive age who wish to conceive, while the use of these antidepressants seems to be justified in women with depression or anxiety who have undergone IVF. Key points SSRIs could cause dose and duration-dependent reversible adverse effects on male fertility parameters. In depressed or anxious male patients of reproductive age who wish to conceive mirtazapine or bupropion should be used because of their lower potential to cause sexual side effects. The results of certain experimental studies indicate that paroxetine and escitalopram may have a negative effect on the fertility of female patients. The use of SSRIs in women with depression or anxiety who have undergone IVF seems to be justified, because these psychiatric disorders reduce the likelihood of becoming pregnant. PMID: 33480810 [PubMed - as supplied by publisher]
Source: International Journal of Psychiatry in Clinical Practice - Category: Psychiatry Tags: Int J Psychiatry Clin Pract Source Type: research