Understanding of the crosstalk between normal residual hematopoietic stem cells and the leukemic niche in Acute Myeloid Leukemia.

The hematopoietic system comprises potent stem and progenitor cells which provide our bodies with a life-long supply of all blood cells. Hematopoietic stem cells (HSCs) are at the apex of the hematopoietic hierarchy, and reside in highly specialized niches within the bone marrow microenvironment, a diverse and complex tissue. Whilst the bone marrow tissue contains a large amount of hematopoietic cells, it also consists of non-hematopoietic components such as mesenchymal stromal cells (MSCs), and its derivatives osteoblasts, adipocytes and is highly vascularised and innervated [1 –3].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Perspective Source Type: research