Adult neurogenesis and antidepressant treatment; the surprise finding by Ron Duman and the field 20 years later

Out of Ron Duman ’s many influential findings, the finding that chronic treatment with antidepressant drugs produces an increase in neurogenesis in the subgranular zone of the adult hippocampus may be one of the most enduring and far-reaching. This novel discovery and his decades of continued research in the field , led to a new hypothesis about the mechanism of action of antidepressants, providing a critical step in our understanding of the neurotrophic hypothesis of depression and synaptic plasticity.
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Review Source Type: research