Ozone inhalation induces exacerbation of eosinophilic airway inflammation and Th2-skew immune response in a rat model of AR.

CONCLUSIONS: O3 inhalation deteriorated symptoms in AR rats, and the possible mechanism is that ozone co-exposure could enhance the expression of Th2 cytokines, eosinophilic airway inflammation dose-dependently. The observation is helpful for us to understand the synergistic effect of O3 in the air pollution and allergen on aggravating allergic rhinitis.
PMID: 33482509 [PubMed - as supplied by publisher]

Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 19, 2021 Category: Drugs & Pharmacology Authors: Sun N, Niu Y, Zhang R, Huang Y, Wang J, Qiu W, Zhang X, Han Z, Bao J, Zhu H, Duan Y, Kan H Tags: Biomed Pharmacother Source Type: research