Understanding the clinical implication of mismatch repair deficiency in endometrioid endometrial cancer through a prospective study.

CONCLUSIONS: MLH1 methylated EECs exhibit more aggressive features compared to other MMRd and MMRi EECs. This may indicate an inherent difference in tumor biology, suggesting the importance of individualized management based on EC molecular phenotype.
PMID: 33478752 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - January 18, 2021 Category: Cancer & Oncology Authors: Kim SR, Tone A, Kim RH, Cesari M, Clarke BA, Eiriksson L, Hart T, Aronson M, Holter S, Lytwyn A, Lajkosz K, Oldfield L, Gallinger S, Bernardini MQ, Oza AM, Djordjevic B, Lerner-Ellis J, Van de Laar E, Vicus D, Pugh T, Pollett A, Ferguson SE Tags: Gynecol Oncol Source Type: research