A Short Discussion About The SARS-CoV-2 mRNA-1273 Vaccine

SARS-CoV-2 has caused an international health crisis that is only second in severity to the 1918 influenza pandemic (Taubenberger and Morens, 2006) and for which current development efforts to contain its wildfire-like spread with a safe and effective vaccine constitute a dire necessity and an immediate call to action; while success with one or more of the vaccine candidates is assumed and anxiously anticipated, it is not guaranteed due to compressed development timelines, the likely lack of results from long term testing, the inchoateness of knowledge regarding betacoronavirus immunology and the correctness of current vaccine strategies, most of which are based on presentation of the mutation-prone Spike protein with the reported potential to lead to exacerbation of disease through antibody dependent enhancement (ADE).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Perspective Source Type: research