Screening for PIK3CA mutations among Saudi women with ovarian cancer.

Screening for PIK3CA mutations among Saudi women with ovarian cancer. J Obstet Gynaecol. 2021 Jan 21;:1-7 Authors: Al-Qahtani WS, Alduwish MA, Al-Olayan EM, Aljarba NH, Em AH, Albani FG, Domiaty DM, Al-Otaibi AM, Qattan SMA, Almurshedi AS, Elasbali AM, Ahmed HG, Almutlaq BA Abstract The study aimed to screen for PIK3CA gene mutations among Saudi women with Ovarian Cancer. The study included 298 Saudi women with epithelial ovarian cancers (EOC). DNA sequence analysis was employed to screen for the mutations. DNA sequence analysis of a coding region of exon 9 and 20 of PIK3CA gene revealed mutations in 37/298 (12.4%) EOC patients. About 21/37(56.8%) somatic mutations were identified in exons 9, and 16/37(43.2%) in exon 20. All analysed mutations were missense mutations, the frequencies of which varied from 2.7% to 43.2%. PIK3CA mutation was found to be significantly associated with age (p = .023), grade (p = .001) and histological types (p = .032). Only 6.6% of serous carcinomas and 3.8% of endometrioid had PIK3CA mutation. The Mutated PIK3CA gene was significantly involved in the pathogenesis of EOC among Saudi women. PIK3CA gene mutation and overexpression represent important clinical implications for diagnosis, and prognosis, which can be utilised for better EOC management. Impact statement What is already known on this subject? The detailed molecular and genetic phenomenon underlying the progression of these tumours is ...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research