DNA Damage and the Aging Epigenome
In mammals, genome instability and aging are intimately linked as illustrated by the growing list of patients with progeroid and animal models with inborn DNA repair defects. Until recently, DNA damage was thought to drive aging by compromising transcription or DNA replication, thereby leading to age-related cellular malfunction and somatic mutations triggering cancer. However, recent evidence suggests that DNA lesions also elicit widespread epigenetic alterations that threaten cell homeostasis as a function of age.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Athanasios Siametis, George Niotis, George A. Garinis Tags: Review Source Type: research