Increased insulin sensitivity and diminished pancreatic beta-cell function in DNA repair deficient Ercc1d/ − mice

Type 2 diabetes (T2DM) is an age-associated disease characterized by hyperglycemia due to insulin resistance and decreased beta-cell function. DNA damage accumulation has been associated with T2DM, but whether DNA damage plays a role in the pathogenesis of the disease is unclear. Here, we used mice deficient for the DNA excision-repair gene Ercc1 to study the impact of persistent endogenous DNA damage accumulation on energy metabolism, glucose homeostasis and beta-cell function.

Source: Metabolism - Clinical and Experimental - January 22, 2021 Category: Biomedical Science Authors: Ana P. Huerta Guevara, Sara J. McGowan, Melissa Kazantzis, Tania Rozgaja Stallons, Tokio Sano, Niels L. Mulder, Angelika Jurdzinski, Theo H. van Dijk, Bart J.L. Eggen, Johan W. Jonker, Laura J. Niedernhofer, Janine K. Kruit Source Type: research