Ultrasound-Mediated Microbubble Cavitation Transiently Reverses Acute Hindlimb Tissue Ischemia through Augmentation of Microcirculation Perfusion via the eNOS/NO Pathway
Ultrasound-mediated microbubble cavitation improves perfusion in chronic limb and myocardial ischemia. The purpose of this study was to determine the effects of ultrasound-mediated microbubble cavitation in acute limb ischemia and investigate the mechanism of action. The animal with acute hindlimb ischemia was established using male Sprague-Dawley rats. The rats were randomly divided into three groups: intermittent high-mechanical-index ultrasound pulses combined with microbubbles (ultrasound [US] + MB group), US alone (US group) and MB alone (MB group).
Source: Ultrasound in Medicine and Biology - Category: Radiology Authors: Shifeng Qiu, Danxia Li, Yuegang Wang, Jiancheng Xiu, Chuangye Lyu, Shelby Kutty, Daogang Zha, Juefei Wu Tags: Original Contribution Source Type: research