Filaggrin variation differs for European-Americans and African-Americans

Atopic dermatitis (AD) is a common chronic illness that often manifests in childhood as red, itchy, inflammatory, crusting skin lesions. However, the disease can occur at any age and waxes and wanes in severity. The most common genetic findings in children with AD are filaggrin (FLG; OMIM:135940) loss of function mutations (LOF) found on the gene ’s third exon. . Europeans with the most severe and persistent forms of AD are more likely to have FLG LOF (Irvine et al., 2011, Margolis et al., 2012).

Source: Journal of Investigative Dermatology - January 21, 2021 Category: Dermatology Authors: Yaqian Zhu, Nandita Mitra, Yuanqing Feng, Sarah Tishkoff, Ole Hoffstad, David Margolis Tags: Letters to the Editor Source Type: research