Pharmacokinetic variability and exposures of fluconazole, anidulafungin and caspofungin in intensive care unit patients: Data from multinational Defining Antibiotic Levels in Intensive care unit (DALI) patients Study

Conclusions:
Considerable inter-individual variability was observed for fluconazole, anidulafungin and caspofungin. A large proportion of the patients (33%) receiving fluconazole did not attain the PK/PD target which might be related to inadequate dosing. For anidulafungin and caspofungin, dose optimisation also appears necessary to minimize variability.

Source: BioMed Central - February 4, 2015 Category: Journals (General) Authors: Mahipal G SinnollareddyJason A RobertsJeffrey LipmanMurat AkovaMatteo BassettiJan J De WaeleKirsi-Maija KaukonenDespoina KoulentiClaude MartinPhilippe MontraversJordi RelloAndrew RhodesTherese StarrSteven C WallisGeorge Dimopouloson behalf of the DALI Stu Source Type: research