The Why behind "Warburg" Effect

Ever wondered why cancer cells undergo Warburg effect , aerobic glycolysis? The why behind it. This interesting paper explores this question. Learning about science unraveling these mysteries is always a pleasure. According tothe article Aerobic glycolysis, or preferential fermentation of glucose-derived pyruvate to lactate despite available oxygen, is associated with proliferation across many organisms and conditions. PDH activation suppresses cell proliferation by reducing the NAD+/NADH ratio Insufficient ATP demand slows mitochondria NAD+ regeneration in proliferating cells Uncoupling mitochondrial respiration from ATP synthesis can increase proliferation Aerobic glycolysis reflects increased cell demand for NAD+ relative to ATP turnoverReference : Increased demand for NAD+ relative to ATP drives aerobic glycolysisAlba Luengo et alPublished:December 30, 2020 DOI:https://doi.org/10.1016/j.molcel.2020.12.012Famous Radiology Blog http://www.sumerdoc.blogspot.com TeleRad Providers at www.teleradproviders.com Mail us at sales@teleradproviders.com
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