Kawasaki disease in African American children

It is well known that Kawasaki disease has racial and ethnic variations in prevalence, response to intravenous gamma globulin, and outcomes. However, relatively little is known about African American children. In this volume of The Journal, Padilla et al report on comparisons between African American and white children with respect to Kawasaki Disease outcomes. They found that African American children were more likely to be refractory to IVIG treatment, have more severe inflammation, and had a greater proportion of persistent coronary artery abnormalities at follow-up compared with white children.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: The Editors' Perspectives Source Type: research

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Reply to Dr. Dahdah's Letter to the Editor Re: "A Four-Year-Old with History of Kawasaki Disease Presenting in Acute Shock". Prehosp Emerg Care. 2020 Oct 07;:1-2 Authors: Donofrio-Ödmann JJ, Remoulet A, Burns J, Harvey H, Staats K PMID: 33026275 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
Publication date: October 2020Source: Canadian Journal of Cardiology, Volume 36, Issue 10Author(s): Warwick Butt
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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Source: Polish Journal of Cardio-Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Kardiochir Torakochirurgia Pol Source Type: research
An alarming increase in children presenting with fever, hyperinflammation, and multiorgan dysfunction frequently requiring intensive care has been observed after severe acute respiratory syndrome coronavirus 2 infection. The illness resembles Kawasaki disease (KD), with coronary dilatation and aneurysm occurring in some. However, the cardiovascular manifestations were typically on the severe end of the KD spectrum, with cardiogenic shock a common presentation together with other features. This led to defining a unique syndrome named multisystem inflammatory syndrome in children (MIS-C). In this issue of the JCI, Lee and Da...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
CONCLUSION MIS-C encompasses a broad phenotypic spectrum with clinical and laboratory features distinct from KD and MAS.FUNDING This work was supported by the National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases; the National Institute of Allergy and Infectious Diseases; Rheumatology Research Foundation Investigator Awards and Medical Education Award; Boston Children’s Hospital Faculty Career Development Awards; the McCance Family Foundation; and the Samara Jan Turkel Center.
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Kawasaki disease (KD) is the most common pediatric systemic vasculitides of unknown etiology. Recent clinical studies led to reappraisal of the usefulness of initial combination therapy of intravenous immunogl...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Research article Source Type: research
AbstractCoronavirus disease 2019 (COVID-19) has affected patients across all age groups, with a wide range of illness severity from asymptomatic carriers to severe multi-organ dysfunction and death. Although early reports have shown that younger age groups experience less severe disease than older adults, our understanding of this phenomenon is in continuous evolution. Recently, a severe multisystem inflammatory syndrome in children (MIS-C), with active or recent COVID-19 infection, has been increasingly reported. Children with MIS-C may demonstrate signs and symptoms of Kawasaki disease, but also have some distinct differ...
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research
Authors: SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY, Conti G, Giannitto N, De Luca FL, Salpietro A, Oreto L, Viola I, Ceravolo A, Nicocia G, Sio A, Romeo M, Ceravolo G, Cuppari C, Calabrò MP, Chimenz R Abstract Kawasaki disease (KD) is an acute systemic vasculitis of unknown etiology. It has a self-limiting course and so far, represents the most common cause of coronary heart disease acquired in children aged between 6 months and 5 years. The inflammatory process can involve the coronary arteries with the formation of aneurysms and thrombotic occlusions with the risk of sudden death, especially in infants....
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
We present 4 patients along with their emergency department course, so providers will have a better understanding of the identification and workup of these patients. Currently, it is unclear when this inflammatory syndrome develops in respect to a COVID-19 infection. The clinical features of this syndrome seem to overlap between Kawasaki disease, toxic shock syndrome, and myocarditis. All patients presenting to our emergency department had fever, variable rash, abdominal pain, vomiting, and/or diarrhea. Patients remained persistently tachycardic and febrile despite being given proper doses of antipyretics. Severity of pres...
Source: Pediatric Emergency Care - Category: Emergency Medicine Tags: Special Features Source Type: research
A small subset of pediatric patients develop a rare syndrome associated with Coronavirus Disease 2019 (COVID-19) infection called multisystem inflammatory syndrome in children (MIS-C). This syndrome shares characteristics with Kawasaki disease.
Source: The Journal of Emergency Medicine - Category: Emergency Medicine Authors: Tags: Clinical Communications: Pediatric Source Type: research
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