Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway.

Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway.
Antimicrob Agents Chemother. 2021 Jan 19;:
Authors: Prater AG, Mehta HH, Beabout K, Supandy A, Miller WR, Tran TT, Arias CA, Shamoo Y
Abstract
LiaFSR signaling plays a major role in mediating daptomycin (DAP) resistance in enterococci, and the lack of a functional LiaFSR pathway leads to DAP hypersusceptibility. Using in vitro experimental evolution, we evaluated how Enterococcus faecium with a liaR response regulator gene deletion evolved DAP resistance. We found that knocking out LiaFSR signaling significantly delayed the onset of resistance, but resistance could emerge eventually through a variety of alternate mechanisms that were influenced by the environment.
PMID: 33468468 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - January 19, 2021 Category: Microbiology Authors: Prater AG, Mehta HH, Beabout K, Supandy A, Miller WR, Tran TT, Arias CA, Shamoo Y Tags: Antimicrob Agents Chemother Source Type: research