Assessment of piperacillin-tazobactam-meropenem synergy against serine carbapenemase producing Enterobacterales using time kill assays.

Assessment of piperacillin-tazobactam-meropenem synergy against serine carbapenemase producing Enterobacterales using time kill assays. Antimicrob Agents Chemother. 2021 Jan 19;: Authors: Lawandi A, Leite GC, Cheng MP, Lefebvre B, Longtin J, Lee TC Abstract Synergy between piperacillin-tazobactam and meropenem against KPC-producing Klebsiella pneumoniae was recently demonstrated. We sought to test the combination against a broader range of serine carbapenemase producers. We tested the combination against 10 KPC-producing E. coli and 10 OXA-48 family producing K. pneumoniae Antibiotic concentrations used are achievable in critically ill patients. The combination was synergistic against 7/10 KPC producers and in 9/10 OXA-48 producers. There was no synergy detected in control isolates producing NDM-1. PMID: 33468471 [PubMed - as supplied by publisher]
Source: Antimicrobial Agents and Chemotherapy - Category: Microbiology Authors: Tags: Antimicrob Agents Chemother Source Type: research