Downregulation of breast cancer resistance protein by long-term fractionated radiotherapy sensitizes lung adenocarcinoma to SN-38

In conclusion, these results presented important data on the sensitivity changes of lung ad enocarcinoma cells to chemotherapeutic drugs after acquiring radioresistance and suggested that irinotecan (the prodrug of SN-38) might be a promising drug candidate for lung adenocarcinoma patients with acquired radioresistance.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research