Highly Enantioselective Cobalt-Catalyzed (3 + 2) Cycloadditions of Alkynylidenecyclopropanes.

Highly Enantioselective Cobalt-Catalyzed (3 + 2) Cycloadditions of Alkynylidenecyclopropanes.
Angew Chem Int Ed Engl. 2021 Jan 19;:
Authors: Da Concepción E, Fernández I, Mascareñas JL, Lopez F
Abstract
Low-valent cobalt complexes equipped with chiral ligands can efficiently promote highly enantioselective (3+2) cycloadditions of alkyne-tethered alkylidenecyclopropanes. The annulation allows to assemble bicyclic systems containing five-membered rings in good yields and with excellent enantiomeric ratios. We also present a mechanistic discussion based on experimental and computational data, which support the involvement of Co(I)/Co(III) catalytic cycles.
PMID: 33464693 [PubMed - as supplied by publisher]

Source: Angewandte Chemie - January 19, 2021 Category: Chemistry Authors: Da Concepción E, Fernández I, Mascareñas JL, Lopez F Tags: Angew Chem Int Ed Engl Source Type: research