Preclinical Development of 18F-OF-NB1 for Imaging GluN2B-Containing N-Methyl-D-Aspartate Receptors and Its Utility as a Biomarker for Amyotrophic Lateral Sclerosis
Conclusion: 18F-OF-NB1 is a highly promising PET probe for imaging the GluN2B subunits of the N-methyl-d-aspartate receptor. It possesses utility for receptor occupancy studies and has potential for PET imaging studies in ALS patients and possibly other brain disorders.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Ahmed, H., Wallimann, R., Haider, A., Hosseini, V., Gruber, S., Robledo, M., Nguyen, T. A. N., Herde, A. M., Iten, I., Keller, C., Vogel, V., Schibli, R., Wunsch, B., Mu, L., Ametamey, S. M. Tags: Basic Source Type: research