68Ga-PSMA PET/CT for Primary Lymph Node and Distant Metastasis NM Staging of High-Risk Prostate Cancer

Conclusion: In this high-risk PCa cohort, we identified advanced disease in about one third at diagnosis. ISUP grade was the superior predictor for advanced disease at diagnosis. We found a significant difference in frequency of advanced disease between ISUP grades 2 and 3, as supports the Gleason score 7 subdivision. Interestingly, we observed no significant differences in risk of advanced disease when comparing the different cT2 stages. The undetected LNMs were either PSMA-negative or micrometastases.

Source: Journal of Nuclear Medicine - January 19, 2021 Category: Nuclear Medicine Authors: Klingenberg, S., Jochumsen, M. R., Ulhoi, B. P., Fredsoe, J., Sorensen, K. D., Borre, M., Bouchelouche, K. Tags: Clinical Source Type: research