Pros and Cons in Using Population-Based Registers for Assessing the Fetal Safety of Drugs

To the Editor Andersson et al investigate the risk of adverse fetal outcomes associated with the use of a second-generation antihistamine (fexofenadine) among 2962 pregnancies with fexofenadine use matched in a 1:1 ratio with those with the use of the currently recommended second-generation antihistamines (cetirizine). No association has been noted between fexofenadine use during pregnancy and increased risk of major birth defects, spontaneous, preterm birth, and stillbirth.
Source: JAMA Pediatrics - Category: Pediatrics Source Type: research