Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses
Conclusions
Fumaric acid esters exhibit different biodistribution and may elicit different biological responses; furthermore, pharmacodynamic effects of combinations differ unpredictably from monotherapy. The strong potential to induce lymphopenia in patients with MS may be a result of activation of apoptosis pathways by MEF compared with DMF.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Wipke, B. T., Hoepner, R., Strassburger-Krogias, K., Thomas, A. M., Gianni, D., Szak, S., Brennan, M. S., Pistor, M., Gold, R., Chan, A., Scannevin, R. H. Tags: All Demyelinating disease (CNS), Multiple sclerosis Article Source Type: research
More News: Brain | Genetics | Multiple Sclerosis | Neurology | PET Scan | Psoriasis | Urology & Nephrology