Different Fumaric Acid Esters Elicit Distinct Pharmacologic Responses

Conclusions Fumaric acid esters exhibit different biodistribution and may elicit different biological responses; furthermore, pharmacodynamic effects of combinations differ unpredictably from monotherapy. The strong potential to induce lymphopenia in patients with MS may be a result of activation of apoptosis pathways by MEF compared with DMF.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: All Demyelinating disease (CNS), Multiple sclerosis Article Source Type: research