Cancers, Vol. 13, Pages 351: EGR1/GADD45 α Activation by ROS of Non-Thermal Plasma Mediates Cell Death in Thyroid Carcinoma

Conclusions: Our findings suggest that NTPAM induces apoptotic cell death in THCA through a novel mechanism by which NTPAM-induced ROS activates EGR1/GADD45α signaling. Furthermore, our data provide evidence that the regulation of the EGR1/GADD45α axis can be a novel strategy for the treatment of THCA.

Source: Cancers - January 19, 2021 Category: Cancer & Oncology Authors: Seung-Nam Jung Chan Oh Jae Won Chang Lihua Liu Mi Ae Lim Yan Li Jin Yudan Piao Hae Jong Kim Ho-Ryun Won Seong Eun Lee Min Joung Lee Jun Young Heo Sangmi Jun Doheon Lee Woo Seok Kang Dae-Woong Kim Ki-Sang Rha Young Il Kim Yea Eun Kang Bon Seok Koo Tags: Article Source Type: research