Predictive Parameters of Decreased Left Ventricular Global Longitudinal Strain at 1 Month After Pediatric Heart Transplantation

In this study, we investigate the predictive capacity of preoperative parameters on the LVGLS decline seen at 1 month post transplant. Forty-six transplant subjects with 2D echocardiographic images sufficient for speckle tracking echocardiography were enrolled. We excluded patients dia gnosed with cardiac allograft vasculopathy or with an episode of rejection 1 month before or after their echocardiographic examinations. The mean LVGLS was significantly reduced at 1 month when compared to 1 year following transplant (− 15.5% vs. − 19.4%, respectively,p <  0.001). The predictors of LVGLS that decline at 1 month were the LV massz-score [odds ratio (OR) 1.452; 95% confidence interval (CI) 1.007 –2.095,p = 0.046], recipient age (OR 1.124; 95% CI 1.015–1.245,p = 0.025), and donor age (OR 1.081; 95% CI 1.028–1.136,p = 0.002) in the univariate logistic regression analyses. Although multivariate analysis yielded no significant predictors, higher LV massz-scores showed a trend associated with the decline of LVGLS (p = 0.087). The donor/recipient weight ratio was associated with the LV massz-score (R2 = 0.412,p <  0.001).
Source: Mammalian Genome - Category: Genetics & Stem Cells Source Type: research