Effect of HIF1 α on the TRPC6 channel of glomerular podocytes under chronic hypoxia.

CONCLUSIONS: TRPC6 mRNA and protein expression levels were significantly increased in podocytes under hypoxia, which may result in the increase of intracellular Ca2+. This alternation of TRPC6 may be relevant to the modulation of HIF1α. Hypoxia in podocytes can result in cytoskeleton reorganization, which further leads to podocytes injury and disfunction.
PMID: 33450580 [PubMed - as supplied by publisher]

Source: Biochemical and Biophysical Research communications - January 12, 2021 Category: Biochemistry Authors: Hu G, He Y, Li Y, Hu X, Liu S, Liao C, Zhang R, Zhou X, Sun H Tags: Biochem Biophys Res Commun Source Type: research