CaMKII δ Met281/282 oxidation is not required for recovery of calcium transients during acidosis.

CONCLUSIONS: Our study shows that oxidative activation of CaMKIId is neither required for recovery of Ca2+-transients during acidosis nor relevant for post-acidic arrhythmias in isolated cardiac myocytes. Moreover, acidosis actually reduces the cytosolic redox potential of isolated cardiac myocytes. Pharmacological inhibition of global CaMKII activity completely prevents recovery of Ca2+-transients and protects from post-acidic arrhythmias in MM-VV myocytes which confirms the relevance of CaMKII activity in the context of acidosis. PMID: 33449853 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33449853?dopt=Abstract

Source: American Journal of Physiology. Heart and Circulatory Physiology - January 15, 2021 Category: Physiology Authors: Kreitmeier KG, Tarnwoski D, Nanadikar MS, Baier MJ, Wagner S, Katschinski DM, Maier LS, Sag CM Tags: Am J Physiol Heart Circ Physiol Source Type: research