Enzymatically-inactive Tissue-type Plasminogen Activator Reverses Disease Progression in the Dextran Sulfate Sodium Mouse Model of Inflammatory Bowel Disease

Enzymatically-inactive tissue-type plasminogen activator (EI-tPA) does not activate fibrinolysis but still interacts with the NMDA Receptor (NMDA-R) and LRP1 in macrophages to block innate immune system responses mediated by Toll-like Receptors. Herein, we examined the ability of EI-tPA to treat colitis in mice induced by Dextran Sulfate Sodium (DSS). In two separate studies, designed to generate colitis of differing severity, a single dose of EI-tPA administered after inflammation was established significantly improved disease parameters.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Short Communication Source Type: research