Single-dose L-dopa increases upper brainstem GABA in Parkinson's disease: A preliminary study

Parkinson's disease (PD) is a heterogeneous neurodegenerative disorder, characterized by the dysfunction between dopaminergic and GABAergic neuronal activities. Dopamine (DA) replacement by its precursor L-dopa remains the primary treatment for PD. In this preliminary study, we test the hypotheses that GABA+ levels would be lower in PD patients than controls, and normalized by L-dopa.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research