Melody valve to replace the mitral valve in small children: Lessons learned

Conclusions: Mitral valve replacement with a Melody valve is feasible in infants, is reproducible, shows good immediate results, and offers the possibility of later dilatation. This technique offers a better solution compared to the existing alternatives for infants requiring a prosthetic mitral valve.
Source: Annals of Pediatric Cardiology - Category: Cardiology Authors: Source Type: research

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BACKGROUND Germline mutations in telomerase and other telomere maintenance genes manifest in the premature aging short telomere syndromes. Myelodysplastic syndromes and acute myeloid leukemia (MDS/AML) account for 75% of associated malignancies, but how these cancers overcome the inherited telomere defect is unknown.METHODS We used ultra-deep targeted sequencing to detect somatic reversion mutations in 17 candidate telomere lengthening genes among controls and patients with short telomere syndromes with and without MDS/AML, and we tested the functional significance of these mutations.RESULTS While no controls carried somat...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Interview with Jayme E. Locke, MD MPH, and Alixandra Cozette Killian, MD MPH, authors of Evaluation of Community-Level Vulnerability and Racial Disparities in Living Donor Kidney Transplant
Source: JAMA Specialty Journals Author Interviews - Category: General Medicine Authors: Source Type: podcasts
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
This article describes a novel technique for primary cleft lip repair that allows for the formation of the Cupid's bow peak without scarring.Plastic and Reconstructive Surgery
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Plastic Surgery & Aesthetic Medicine Journal Article Source Type: news
Curr Med Chem. 2021 Sep 13. doi: 10.2174/0929867328666210914115411. Online ahead of print.ABSTRACTIn recent years, knowledge of cardiac regeneration mechanisms has dramatically expanded. Regeneration can replace lost parts of organs, common among animal species. The heart is commonly considered an organ with terminal development, which has no reparability potential during post-natal life; however, some intrinsic regeneration capacity has been reported for cardiac muscle, which opens novel avenues in cardiovascular disease treatment. Different endogenous mechanisms were studied for cardiac repairing and regeneration in rece...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
CONCLUSIONS: Although not all patients gain weight after kidney transplantation, the different evolution of weight does not influence graft survival.PMID:34521566 | DOI:10.1016/j.nefro.2021.08.001
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Authors: Source Type: research
Int J Med Sci. 2021 Jul 25;18(15):3361-3366. doi: 10.7150/ijms.62903. eCollection 2021.ABSTRACTFerroptosis is an iron-dependent form of regulated cell death, which is characterized by a large amount of lipid peroxide accumulation and the imbalance of redox state in cells. Ferroptosis is usually accompanied with the dysfunction of lipid repair enzyme (glutathione peroxidase 4, GPX4), large masses of iron accumulation and lipid peroxidation of polyunsaturated fatty acids (PUFAs). Ferroptosis is related to several signaling pathways, including amino acid and iron metabolism, ferritinophagy, cell adhesion and p53 and Keap1/Nrf...
Source: International Journal of Medical Sciences - Category: Biomedical Science Authors: Source Type: research
This article is protected by copyright. All rights reserved.PMID:34523154 | DOI:10.1111/boc.202100035
Source: Biology of the Cell - Category: Cytology Authors: Source Type: research
Conclusion Efficient multidisciplinary approach is essential in the management of PA-AML and cardiac disease. Minimally invasive cardiac surgery may be safe and useful in patients with AML. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: The Thoracic and Cardiovascular Surgeon Reports - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Case Report: Cardiac Source Type: research
Publication date: February 2017 Source:Cancer Epidemiology, Volume 46 Author(s): Susan E. Carozza, Harold Bae, Thomas Meath, Adam Branscum, Marit L. Bovbjerg, Peter H. Langlois Children with Down syndrome (DS) have a remarkably high risk of developing leukemia during childhood; the mechanisms driving that risk are not well understood, and no clear prevention strategies exist. We conducted a nested case-control study in a Texas DS birth cohort to investigate possible links between maternal health, labor/delivery conditions, and leukemia risk. For most of the factors studied there was no evidence of an increased risk of tot...
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
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