Cancers, Vol. 13, Pages 315: Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases
Cancers, Vol. 13, Pages 315: Thymic Hyperplasia with Lymphoepithelial Sialadenitis (LESA)-Like Features: Strong Association with Lymphomas and Non-Myasthenic Autoimmune Diseases
Cancers doi: 10.3390/cancers13020315
Authors:
Stefan Porubsky
Zoran V. Popovic
Sunil Badve
Yara Banz
Sabina Berezowska
Dietmar Borchert
Monika Brüggemann
Timo Gaiser
Thomas Graeter
Peter Hollaus
Katrin S. Huettl
Michaela Kotrova
Andreas Kreft
Christian Kugler
Fabian Lötscher
Burkhard Möller
German Ott
Gerhard Preissler
Eric Roessner
Andreas Rosenwald
Philipp Ströbel
Alexander Marx
Thymic hyperplasia (TH) with lymphoepithelial sialadenitis (LESA)-like features (LESA-like TH) has been described as a tumor-like, benign proliferation of thymic epithelial cells and lymphoid follicles. We aimed to determine the frequency of lymphoma and autoimmunity in LESA-like TH and performed retrospective analysis of cases with LESA-like TH and/or thymic MALT-lymphoma. Among 36 patients (21 males) with LESA-like TH (age 52 years, 32–80; lesion diameter 7.0 cm, 1–14.5; median, range), five (14%) showed associated lymphomas, including four (11%) thymic MALT lymphomas and one (3%) diffuse large B-cell lymphoma. One additional case showed a clonal B-cell-receptor rearrangement without evidence of lymphoma. Twelve (33%) patients (7 women) suffered from partially overlapping autoimmune diseases: systemic lupus erythematosus (n = 4, 11%), rheumat...
Source: Cancers - Category: Cancer & Oncology Authors: Stefan Porubsky Zoran V. Popovic Sunil Badve Yara Banz Sabina Berezowska Dietmar Borchert Monika Br üggemann Timo Gaiser Thomas Graeter Peter Hollaus Katrin S. Huettl Michaela Kotrova Andreas Kreft Christian Kugler Fabian L ötscher Burkhard M öller Ger Tags: Article Source Type: research
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