Serotonin plays a key role in the development of opioid-induced hyperalgesia in mice
Opioids are essential for the management of perioperative pain as well as palliative treatment of cancer pain. However, chronic administering of opioids may cause a reduction in the analgesic effect (tolerance), and lead to paradoxical hyperalgesia (opioid-induced hyperalgesia (OIH)) and subsequent physical dependency.2,24,47 More specifically, OIH is often associated with a requirement for increased, and often long-term, administering of opioids, which worsen tolerance, resulting in physical and mental dependence.
Source: The Journal of Pain - Category: Materials Science Authors: Mika Sasaki, Yoshinori Kamiya, Keiko Bamba, Takeshi Onishi, Keiichiro Matsuda, Tatsuro Kohno, Miyuki Kurabe, Kenta Furutani, Harue Yanagimura Tags: Original Reports Source Type: research
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