Effects of selective TNFR1 inhibition or TNFR2 stimulation, compared to non-selective TNF inhibition, on (neuro)inflammation and behavior after myocardial infarction in male mice.

CONCLUSION: Early receptor interventions, but not non-specific TNF inhibition, increased mortality. Apart from this undesired effect, the general beneficial profile after TNFR2 stimulation, rather than the unfavourable effects of TNFR1 inhibition, would render TNFR2 stimulation preferable over non-specific TNF inhibition in MI with comorbid depression. However, follow-up studies regarding optimal timing and dosing are needed. PMID: 33444731 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33444731?dopt=Abstract

Source: Brain, Behavior, and Immunity - January 11, 2021 Category: Neurology Authors: Gouweleeuw L, Wajant H, Maier O, Eisel ULM, Blankesteijn WM, Schoemaker RG Tags: Brain Behav Immun Source Type: research