Association Between Methadone or Buprenorphine Use During Medically Supervised Opioid Withdrawal and Extended-Release Injectable Naltrexone Induction Failure

Extended-release naltrexone (XR-NTX) is an effective maintenance treatment for opioid use disorder, but induction from active opioid use is a challenge as individuals must complete detoxification before induction. We aimed to determine whether use of methadone or buprenorphine, long acting agonist opioids commonly used for detoxification, were associated with decreased likelihood of induction onto XR-NTX.

Source: Journal of Substance Abuse Treatment - January 15, 2021 Category: Addiction Authors: Matisyahu Shulman, Tse-Hwei Choo, Jennifer Scodes, Martina Pavlicova, Jonathan Wai, Patrick Haenlein, Babak Tofighi, Aimee N.C. Campbell, Joshua D. Lee, John Rotrosen, Edward V. Nunes Source Type: research