Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes.

Dissociable effects of dietary sodium in early life upon somatic growth, fluid homeostasis, and spatial memory in mice of both sexes. Am J Physiol Regul Integr Comp Physiol. 2021 Jan 13;: Authors: Segar JL, Grobe CC, Balapattabi K, Ritter ML, Reho JJ, Grobe JL Abstract Postnatal growth failure is a common morbidity for preterm infants and is associated with adverse neurodevelopmental outcomes. While sodium (Na) deficiency early in life impairs somatic growth, its impact on neurocognitive functions have not been extensively studied. We hypothesized that Na deficiency during early life is sufficient to cause growth failure and program neurobehavioral impairments in later life. C57BL/6J mice were placed on low (0.4), normal (1.5), or high (3 g/kg) Na chow at weaning (PD22) and continued on the diet for 3 weeks (to PD40). Body composition and fluid distribution were determined serially by time-domain NMR and bioimpedance spectroscopy, and anxiety, learning, and memory were assessed using the Elevated Plus Maze and Morris Water Maze paradigms in later adulthood (PD63-PD69). During the diet intervention, body mass gains were suppressed in the low- compared to normal- and high-Na groups despite similar caloric uptake rates across groups. Fat mass was reduced in males but not females fed low-Na diet. Fat-free mass and hydration were significantly reduced in both males and females fed the low-Na diet, though rapidly corrected after return to ...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research