Regulation of the epigenetic landscape by immune cell oxidants.

Regulation of the epigenetic landscape by immune cell oxidants.
Free Radic Biol Med. 2021 Jan 11;:
Authors: Das AB, Seddon AR, O'Connor KM, Hampton MB
Abstract
Excessive production of microbicidal oxidants by neutrophils can damage host tissue. The short-term response of cells to oxidative stress is well understood, but the mechanisms behind long-term consequences require further clarification. Epigenetic pathways mediate cellular adaptation, and are therefore a potential target of oxidative stress. Indeed, there is evidence that many proteins and metabolites involved in epigenetic pathways are redox sensitive. In this review we provide an overview of the epigenetic landscape and discuss the potential for redox regulation. Using this information, we highlight specific examples where neutrophil oxidants react with epigenetic pathway components. We also use published data from redox proteomics to map out known intersections between oxidative stress and epigenetics that may signpost helpful directions for future investigation. Finally, we discuss the role neutrophils play in adaptive pathologies with a focus on tumour initiation and progression. We hope this information will stimulate further discourse on the emerging field of redox epigenomics.
PMID: 33444713 [PubMed - as supplied by publisher]

Source: Free Radical Biology and Medicine - January 11, 2021 Category: Biology Authors: Das AB, Seddon AR, O'Connor KM, Hampton MB Tags: Free Radic Biol Med Source Type: research