ILC3-derived acetylcholine promotes protease-driven allergic lung pathology

Initiation of allergic airway pathology often depends on the protease activity of the inhaled allergen. Previous studies have shown that IL-17 –driven neutrophil and eosinophil responses can promote allergic pathology1 and are associated with an initial epithelial release of IL-23, which is accepted as important in promoting TH17 and group 3 innate lymphoid cell (ILC3) responses. ILC3s are a developmentally and phenotypically diverse inn ate lymphoid cell (ILC) subset that includes natural killer (NK) cell receptor (NCR)-positive and NCR-negative populations (NCR+ ILC3s and NCR– ILC3s) as well as CCR6+ lymphoid tissue inducer cells.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research