Meta-Analysis Comparing the Safety and Efficacy of Single vs. Dual Antiplatelet Therapy in Post Transcatheter Aortic Valve Implantation Patients.

The relative safety and efficacy of aspirin versus dual antiplatelet therapy (DAPT; aspirin+clopidogrel) in patients who underwent transcatheter aortic valve implantation (TAVI) and did not have a long-term indication for oral anticoagulation remains controversial. Digital databases were searched to identify relevant articles. The major safety endpoint was bleeding, while the efficacy endpoints included post-TAVI ischemic and thrombotic events. Data were analyzed using a random effect model to calculate the pooled unadjusted odds ratio (OR) for dichotomous outcomes.

Source: The American Journal of Cardiology - January 14, 2021 Category: Cardiology Authors: Waqas Ullah, Mohamed Zghouzi, Bachar Ahmad, Suman Biswas, Nathan Zaher, Yasar Sattar, Homam Moussa Pacha, Andrew M. Goldsweig, Poonam Velagapudi, David L. Fichman, Anand Prasad, M. Chadi Alraies Source Type: research