The accumulation rate of tau aggregates is higher in females and younger amyloid-positive subjects

In conclusion, in this longitudinal PET study comprising four cohorts, we found that the tau accumulation rate is greater in females and younger amyloid-β-positive individuals, while amyloid-β accumulation is great er inAPOEε4 carriers and older individuals. These findings are important considerations for the design of clinical trials, and might improve our understanding of factors associated with faster tau aggregation and spread.
Source: Brain - Category: Neurology Source Type: research